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Evening rain followed by a mix of rain and snow showers overnight. Low 34F. Winds SSE at 5 to 10 mph. Chance of precip 90%..
Evening rain followed by a mix of rain and snow showers overnight. Low 34F. Winds SSE at 5 to 10 mph. Chance of precip 90%.
Updated: December 15, 2022 @ 8:44 pm
BOSTON–(BUSINESS WIRE)–Dec 15, 2022–
Astria Therapeutics, Inc. (NASDAQ:ATXS), a biopharmaceutical company developing STAR-0215 for the treatment of hereditary angioedema (HAE), today announced positive preliminary results from the Phase 1a clinical trial of STAR-0215 in healthy subjects establishing early proof of concept of STAR-0215 as a potential long-acting preventative treatment for HAE. STAR-0215 was well-tolerated at all doses studied. The results showed rapid and sustained drug levels consistent with clinical benefit and sustained target engagement with plasma kallikrein inhibition for at least three months, supporting the potential for STAR-0215 to be dosed once every three months or less frequently. Astria plans to initiate the ALPHA-STAR Phase 1b/2 trial in HAE patients in Q1 2023.
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Copyright Business Wire 2022.
Thursday, Dec. 15
Thursday, Dec. 15
Thursday, Dec. 15
FGFTRebLEHIGHMinM-AM-AO-TAPFPTSAlamudun312-50-00-5214Parolin353-70-02-5136Higgins347-110-00-20115Taylor337-102-20-21218Whitney-Sidney304-80-00-4218Fenton130-30-00-0120Betlow101-30-00-0103Sinclair60-10-00-1100Knostman30-00-00-0000Momah31-20-01-1012Chebuhar20-10-00-0000Totals20025-512-23-2091156
LEHIGH (4-5)
All Times EST
Documents released in the 2021 dropped prosecution of the Colorado gay nightclub shooter paint a picture of potential missteps by prosecutors. Court transcripts reveal prosecutors were unable to successfully serve witnesses in a 2021 kidnapping case against Anderson Aldrich and did not argue to keep the case alive when the judge moved this July to dismiss it. That raises more questions about whether enough was done to stop the recent mass shooting. Police say Aldrich attacked patrons at Club Q in Colorado Springs on Nov. 19 killing five people and wounding 17 with an AR-15-style rifle.
The New York Yankees have added Carlos Rodón to their rotation, agreeing to a $162 million, six-year contract with the left-hander. A person familiar with the negotiations confirmed the contract to The Associated Press on condition of anonymity because it was pending a physical. New York took care of its most pressing question when it convinced AL MVP Aaron Judge to stay in the Bronx with a $360 million, nine-year contract — baseball’s biggest free agent deal ever. But the contract for Rodón is an addition for the reigning AL East champions. Rodón went 14-8 this year with a 2.88 ERA in his lone season with the San Francisco Giants,
LOS ANGELES — Baker Mayfield had 48 hours to get ready for what turned out to be a historic performance.
Tom Brady likes what he’s seen of Joe Burrow. Brady says Burrow is a great young player who’s living up to high expectations for him with the Cincinnati Bengals. The seven-time Super Bowl champion and the top pick in the 2020 draft meet for the first time when Brady’s Tampa Bay Buccaneers host the Bengals. Cincinnati has won five straight games and seven of eight overall to rebound from a slow start. The Bengals appear capable of making another deep playoff run. At 6-7, the sputtering Bucs are in first place in the NFC South despite having a losing record.
Louisiana law enforcement officers have been charged with state crimes for their roles in the deadly 2019 arrest of Ronald Greene. The charges range from negligent homicide to malfeasance. They were handed down by a grand jury on Thursday. Police had initially blamed the Black motorist’s death on a car crash at the end of a high-speed chase in rural northeast Louisiana. But then The Associated Press obtained and published long-suppressed body-camera video that showed white officers beating, stunning and dragging Greene as he pleaded for mercy and wailed, “I’m scared!” These are the first charges to emerge from Greene’s death. They follow yearslong investigations that have expanded to examine whether police brass concealed evidence of troopers beating other Black motorists.
More questions than answers are surfacing at a conference in Las Vegas about what to do about projected shortages of Colorado River water relied upon by seven U.S. states, Native American tribes and Mexico. Some include: Who will bear the brunt of more water supply cuts, and how quickly? What target goals need to be met for voluntary cutbacks before the federal government steps in? What about controlling water evaporation from reservoirs and canals? Officials said Thursday during the Colorado River Water Users Association conference they don’t have answers yet. But they agree the key question is how to live with less. Federal water managers at the Bureau of Reclamation have set a Tuesday deadline for public comments about possible actions.
WASHINGTON — President Joe Biden announced he plans to travel to Africa as he participated in a summit in Washington with leaders from the continent.
Bill Moos wants to tell you about the time he met Mike Leach.
LAS VEGAS — The Nevada Board of Pardons will consider whether to commute all death sentences in the state during a meeting scheduled for Tuesday.
Almost six decades after President John F. Kennedy’s assassination while he was riding in a motorcade in downtown Dallas, questions linger about who else, besides Lee Harvey Oswald, the accused gunman, might have been involved in what a 1979 congressional investigation report called a “consp…
OAKLAND, California — The Alameda County District Attorney’s Office charged three alleged San Francisco gang members with multiple felonies Thursday after their arrests in connection with last year’s fatal shooting of a 23-month-old boy riding in a car on Interstate 880.
FORT WORTH, Texas — Shouts erupted outside a Tarrant County courtroom Thursday as activists and community leaders decried that a former Fort Worth officer found guilty of manslaughter wouldn’t face a more serious conviction for fatally shooting Atatiana Jefferson in 2019.
5 Louisiana law enforcement officers charged with state crimes in deadly 2019 arrest of Black motorist Ronald Greene.
Dec. 9-15, 2022
Post-pandemic, CDC faces ‘uphill battle’ for backing in new Congress
DALLAS — Tyrell Terry, the Mavericks’ No. 31 overall pick in the 2020 draft, announced his retirement from basketball, via an Instagram post on Thursday.
Panama’s government has ordered the local subsidiary of a Canadian mining company to cease operations at its huge open pit copper mine after it failed to sign a new contract outlining substantially higher payments to the government. Minera Panama is a subsidiary of Canada’s First Quantum Minerals Ltd. It is the largest private investment in the history of Panama, employs thousands and accounts directly and indirectly for some 3% of Panama’s gross domestic product. A government statement says President Laurentino Cortizo’s Cabinet voted Thursday to order the mine to stop operations. The Labor Ministry was instructed to take steps that will guarantee employment and labor protections for the mine’s workers.
California air regulators approve roadmap to dramatically slash fossil fuel demand, reach carbon neutrality by 2045.
Peruvian judge approves 18-month detention for ousted President Castillo as officials build case he incited rebellion.
Alaska state Rep. David Eastman has testified that anyone who broke the law during the attack on the U.S. Capitol on Jan. 6, 2021, should be prosecuted. However, he stopped short of calling out the far-right group Oath Keepers by name. Eastman is accused of violating the Alaska state Constitution’s disloyalty clause over his lifetime membership in the Oath Keepers. The constitution states anyone who is a member of a group that advocates the overthrow of the U.S. government should be disqualified from holding office. The presiding judge in the case declined to dismiss the case against Eastman after the plaintiff’s attorney rested his case.
A Malaysia fire department official says some 50 people are feared buried after a landslide hit a campsite outside Kuala Lumpur early Friday. Local media cited police as saying initial information indicated that some 100 people may have been at the campsite in Batang Kali, 25 miles north of Kuala Lumpur, when the incident occurred. A fire department official told The Associated Press that rescuers are searching for an estimated 50 missing people. He provided no further details.
MASON, Ohio–(BUSINESS WIRE)–Dec 15, 2022–
PITTSBURGH — The strange midweek quarterback competition at Steelers headquarters this week might not be a competition after all. Offensive coordinator Matt Canada might have tipped the hand of the coaching staff when he met with reporters Thursday morning.
Chicago Bears quarterback Justin Fields grew up as a fan of Michael Vick. He’s closing in on a feat accomplished only by Vick and Baltimore’s Lamar Jackson. Fields needs 95 yards rushing to become the third NFL quarterback to rush for 1,000 yards in a season. The Bears face the Philadelphia Eagles and their intimidating pass rush on Sunday. The Bears have talked about cutting back on planned running plays by Fields. But he’s always a threat to scramble under pressure. His off-script runs have helped the Bears rank sixth in the NFL in third-down conversion rate.
Trust has Applied to OTCQX®
A bill to rescind the COVID-19 vaccine mandate for members of the U.S. military and provide nearly $858 billion for national defense has passed the Senate and now goes to President Joe Biden to be signed into law. The bill approved Thursday night authorizes about $45 billion more for defense programs than Biden requested and roughly 10% more than last year’s bill. Lawmakers are trying to account for inflation and boost the nation’s military competitiveness with China and Russia. It includes a 4.6% pay raise for servicemembers and the Defense Department’s civilian workforce.
50 people feared buried after Malaysian landslide hits campsite, says fire department.
A California sex offender who kidnapped, raped and killed four women, some of them while wearing a GPS tracker, has been sentenced to life in prison without parole. Prosecutors say 36-year-old Franc Cano was sentenced Thursday in Orange County after pleading guilty to murder and other charges. Cano acknowledged killing a woman whose nude body was found at an Anaheim recycling center in 2014. He also acknowledged killing three others whose bodies were never found. Prosecutors say Cano committed the crimes with his best friend, another sex offender named Steven Gordon, who was convicted in 2016 and sentenced to death.
Oysters harvested in Texas are possibly contaminated with norovirus, sickening dozens of people across several states, authorities say.
PHILADELPHIA — The Central Bucks school board is advancing a policy that would ban staff members from advocating to students about “partisan, political or social policy issues,” a proposal critics said would have a chilling effect on teachers.
Senate OKs defense policy bill raising pay for troops, rescinding vaccine mandate; now goes to Biden for signature.
DENVER — Mayor Michael Hancock issued an emergency declaration for the city and county of Denver on Thursday in response to the surge of migrants who have arrived over the past 10 days.
Prosecutors say a Northern California toddler fatally struck by a stray bullet while sleeping in his car seat last year was the victim of a rolling gun battle between rival gangs on a freeway. The 1-year-old boy, Jasper Wu, was killed Nov. 6, 2021, on Interstate 880 in Oakland when his mother’s car got caught in the crossfire. The Alameda County District Attorney’s Office filed murder charges Thursday against Trevor Green, Ivory Bivins and Johnny Jackson. A fourth suspect, Keison Lee, was killed in a separate shooting last month. It was not immediately clear whether the suspects had attorneys who could speak on their behalf.
Two people were injured when a single-engine plane crashed shortly after takeoff from Lihue Airport on Kauai Island in Hawaii. The Federal Aviation Administration says there were two people on board the plane Beechcraft BE77 which crashed around noon Thursday. The Kauai Fire Department says the injured were taken to a medical center in stable but serious condition. The state Department of Transportation says the plane went down off Lihue Airport property and the crash didn’t affect commercial flights. Firefighters, police officers and paramedics responded to the crash.
